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KMID : 0378019750180121535
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New Medical Journal
1975 Volume.18 No. 12 p.1535 ~ p.1539
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Therapeutic Effects of Minocycline (MINOCIN) Intravenously Injected in Severely Infected Surgical Patients.
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Abstract
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Minocycline is a semi-synthetic new member of the tetracycline family which has a broader antibacterial spectrum and is more potent than tetracycline.
Its chemical name is 7-dimethylamino-6-deoxy-6-demethyltetracycline. It has advantages compared with tetracycline;
1. Therapeutic dose is 8 to 31 times smaller and therapeutic blood concentration is 2 to 6 times lower and persists in plasma for relatively long periods in mice.
2. It is not only active against tetracycline-sensitive strains of staphylococcus aureus, but also is effective against tetracycline-resistant strains of staphylococci, E. coli, enterobacter, proteus and other gram negative bacilli isolated from hospital patients.
3. Bacteria resistence to Minocycline develops slowly in stepwise fashion and is of lower order of magnitude than resistence to tetracycline.
23 patients who had severely intrabdominal contamination, admitted to Department of Surgery, Yonsei University, College of Medicine, were intravenously injeded with Minocycline for 5 to 16 days.
The therapeutic dose of Minocycline was about 10 times smaller than that of tetracycline against infections due to staphylococci, streptococci, E. coli, enterobacter, proteus and other gram negative bacilli. But, Minocycline had not singnificantly active against aerobacter, pseudomonas and klebsiella.
Daily intravenous dose of 200 mg. of Minocycline had well tolerated, while dose in excess of 600 mg. had usually poorly tolerated. Diziness was always occurred
Over-all cure rates was about 78% in our 23 patients. 9 out of 23 patients responded excellently, 9 out of them responded good, while remaining 5 patients responded poorly.
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